Behaviours and environment can change the way your genes work through a mechanism known as epigenetics, which act as a switch that turns genes on or off. The EU-funded EPIVINF project aims to understand how acute viral infections alter the epigenetic regulation of host genes that are governing immune control and neurological health. EPVINF will also investigate how pre-existing epigenetics impact immune response to vaccination. The study will focus on HIV and SARS-CoV-2 as two human viral pathogens that affect millions of people around the globe and share common features that require further research. The study also aims to identify the predisposing factors leading to specific clinical symptoms and how these could be employed as novel therapeutic targets.